Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study

S Liu; I Agartz; P Allen; GP Amminger; OA Andreassen; P Bachman; I Baeza; H Baldwin; CF Bartholomeusz; S Borgwardt; S Catalano; X Chen; KIK Cho; S Choi; T Colibazzi; RE Cooper; CM Corcoran; VL Cropley; L de Haan; C de la Fuente-Sandoval; M Dolz; BH Ebdrup; A Fortea; P Fusar-Poli; LB Glenthøj; BY Glenthøj; SS Haas; HK Hamilton; KM Haut; RA Hayes; Y He; K Heekeren; WTV Hegelstad; CI Hooker; LE Horton; D Hubl; WJ Hwang; M Kaess; K Kasai; N Katagiri; M Kim; J Kindler; MJ Klaunig; S Koike; TD Kristensen; YB Kwak; JS Kwon; SM Lawrie; I Lebedeva; ILJ Lemmers-Jansen; P León-Ortiz; A Lin; RL Loewy; X Ma; DH Mathalon; P McGorry; P McGuire; C Michel; R Mizrahi; M Mizuno; P Møller; R Mora-Durán; D Muñoz-Samons; B Nelson; T Nemoto; M Nordentoft; D Nordholm; MA Omelchenko; L Ouyang; C Pantelis; JC Pariente; JM Raghava; PE Rasser; F Resch; F Reyes-Madrigal; LF Rivera-Chávez; JI Røssberg; W Rössler; DF Salisbury; D Sasabayashi; U Schall; J Schiffman; A Schmidt; L Smigielski; ME Sørensen; G Sugranyes; M Suzuki; T Takahashi; CK Tamnes; J Tang; A Theodoridou; SI Thomopoulos; AS Tomyshev; J Tor; PJ Uhlhaas; TG Værnes; TAMJ van Amelsvoort; D Velakoulis; E Via; S Vinogradov

Journal article

Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study

S Liu, I Agartz, P Allen, GP Amminger, OA Andreassen, P Bachman, I Baeza, H Baldwin, CF Bartholomeusz, S Borgwardt, S Catalano, X Chen, KIK Cho, S Choi, T Colibazzi, RE Cooper, CM Corcoran, VL Cropley, L de Haan, C de la Fuente-Sandoval Show all

Molecular Psychiatry | Published : 2026

DOI: 10.1038/s41380-025-03304-6

Abstract

Brain network architecture is anticipated to influence future grey matter loss in individuals at Clinical High Risk (CHR) for psychosis. However, existing studies on grey matter structural network properties in CHR are scarce and constrained by small sample sizes. Here, we examined network topology differences comparing a) CHR versus healthy controls (HC); b) CHR who transitioned to psychosis (CHR-T) versus those who did not (CHR-NT); and c) different subsyndromes. We included structural scans from 1842 CHR individuals and 1417 HC individuals from 31 sites within the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium. At the global level, CHR individuals exhibited lowe..

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University of Melbourne Researchers

Paul Amminger Author

Cali Bartholomeusz Author

Vanessa Cropley Author

Patrick McGorry Author

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Grants

Awarded by Ministry of Science and ICT, South Korea

Keywords

Enigma Clinical High Risk for Psychosis Working Group

32 Biomedical and Clinical Sciences

Mental Health

Neurosciences

Serious Mental Illness

5202 Biological Psychology